Aptamer‑functionalized EGCG nanocarrier for neutrophil‑targeted AKBA delivery promotes anxiety‑related fracture healing

Fracture healing Research Background:

Clinical observations indicate anxiety can interfere with post‑fracture repair, yet the underlying immunological regulatory logic remains poorly understood, with few corresponding targeted intervention strategies. Animal models reveal abnormal expansion of TGFβ1⁺CCR5⁺ double‑positive neutrophils in bone marrow. These cells form a negative feedback loop with bone marrow mesenchymal stem cells, continuously hampering bone‑tissue repair.

Fracture healing Research Innovations:

This work identifies a neutrophil‑associated regulatory pathway linking anxiety to bone repair impairment. It verifies that AKBA binds to the YAP1 protein to modulate the downstream USP31‑NF‑κB‑CCR5 cascade. It down‑regulates pathogenic neutrophil subsets and restores the osteogenic potential of stem cells, explaining the connection between psychological stress and bone injury at the immune‑cell level.

Fracture healing Material Research:

To address AKBA’s drawbacks of poor solubility and insufficient targeting capacity, the NIMP‑R14 aptamer‑modified EGCG nanocarrier AKBA@E‑N is constructed. The carrier responds to the acidic microenvironment at fracture sites and improves neutrophil uptake and local retention. In‑vivo tests show this nano‑delivery system yields better bone‑repair‑related outcomes than free agents.

Note: This is only cutting‑edge trend sharing and does not constitute any relevant advice.

#Biomaterials #Nanodelivery #Neutrophils #BoneRepair #BioactiveMaterials