Macrophages Intracellularly Gelated With Bioactive Hydrogels for Synergistic Neutralization, Eradication, and Osteopromotion in Periodontitis Treatment

Research Background: （Hydrogels）

Periodontal‑related lesions can trigger alveolar bone loss. Conventional approaches mostly only target pathogenic bacteria, ignoring toxin clearance and bone‑tissue repair. Macrophages inherently recognize various pathological stimuli, yet native macrophages are vulnerable to inflammatory disturbances, limiting their direct application. Multifunctional integrated biomaterials are urgently needed to resolve microenvironmental imbalance.

Research Innovations:

This work constructs intracellularly gelated PZ‑GMs macrophages. The intrinsic recognition‑neutralizing capacity of macrophage membranes is preserved, while phytic acid and zinc ions endow additional intracellular functions. Combined with pH‑responsive injectable carriers, targeted release occurs under inflammatory acidic conditions. Different from single‑function materials, it integrates multiple capabilities to coordinate microenvironment modulation and tissue reconstruction.

Material Research:

PZ‑GMs efficiently capture harmful components. Phytic acid enables in‑situ mineralization and zinc ions further boost performance. The carrier hydrogel features injectability and self‑healing properties. Animal studies verify its capacity to reshape local microecology and optimize tissue‑related indicators, offering an innovative cell‑based design for biomaterials targeting inflammatory bone defects.

Note: This is only cutting‑edge trend sharing and does not constitute any relevant advice.

#Biomaterials #Macrophage #Hydrogel #TissueRegeneration #AdvancedMaterials